Tinospora cordifolia possesses neuroprotective, hepatoprotective, antistress, antiulcer and antipyretic properties. In the early 1900s, giloin, gilenin, and gilosterol were found in the Tinospora cordifolia together with the bitter principles. More recently, a wide variety of sesquiterpenes and diterpenes have been isolated from the stems of Tinospora cordifolia. Tinospora cordifolia contains tinosporine, tinosporide, tinosporidine, tinosporaside, tinosponone, tinocordioside, tinocordiside, tinocordifolin, tinocordifolioside, cordifolide, cordifol, cordifolone, columbin, isocolumbin, chasmanthin, cordioside, cordiofolisides A, B, and C, clerodane furano diterpene, phenylpropanoids, diterpene furon glycosides, palmatosides C and F, palmarin, palmatine, tetrahydropalmatine, berberine and b-sitosterol. Ecdysterone, makisterone A, 20a-hydroxyecdysone are the phytoecdysones isolated from aerial parts of Tinospora cordifolia. Other constituents reported from Tinospora cordifolia include a new phenolic lignan and the following compounds: octacosanol, heptacosanol, alpha-sitosterol, magnoflorine, tembetarine, jatrorrhizine, syringine and syringine apiosylglycoside. Sesquiterpenes and diterpenes isolated from Tinospora cordifolia inhibit growth & spread of various cancers including cancers of lung,cervix, throat and malignant ascites. Polysaccharide fraction isolated from Tinospora cordifolia inhibits lung metastasis. Arabinogalactan, syringine, cordiol, cordioside, cordifoliosides (A & B) isolated from Tinospora cordifolia possesses significant immunoenhancing activity. Tinospora cordifolia provides protection against chemotherapy induced leucopenia. Tinospora cordifolia reduces side effects of radiotherapy and chemotherapy.